多发性硬化系中枢神经系统脱髓鞘性疾病,容易伴发抑郁障碍,其病因不明,与精神心理因素、中枢性炎性病灶、免疫学异常、神经系统结构和功能的改变等相关,发病机制不详,临床表现常出现精神运动迟缓、睡眠障碍、认知改变和疲劳等二者共有的症状,量表应用至今尚未形成统一的方法及标准,诊治缺乏系统研究,治疗多发性硬化的皮质激素和β-干扰素对抑郁障碍发生的影响仍存在争议,故诊治复杂又困难。 Multiple sclerosis Central nervous system demyelinating disease, easily accompanied by depression, its etiology is unknown, and mental and psychological factors, central inflammatory lesions, immunological abnormalities, changes in the structure and function of the nervous system and so on, the pathogenesis Unknown, clinical manifestations often appear mental retardation, sleep disorders, cognitive changes and fatigue, the two common symptoms, the application of the scale has not yet formed a unified method and standard, lack of systematic diagnosis and treatment of corticosteroids and treatment of multiple sclerosis and The impact of interferon beta on the incidence of depression remains controversial and complicated and difficult to diagnose and treat.