氯吡格雷是一种广泛用于冠心病患者的抗血小板药物。但是氯吡格雷不是对所有病人都有同样效果。有些病人尽管进行了氯吡格雷治疗,依然发生了不良事件。这可以被氯吡格雷的抗血小板凝集能力下降所部分解释。一个离体研究定义这一现象为氯吡格雷无应答或抵抗。然而不管是流行病学资料还是和冠心病风险的相关性都不明朗。现对氯吡格雷抵抗的定义、影响因子、临床意义及解决的途径和问题做一综述。 Clopidogrel is a widely used antiplatelet agent in patients with coronary heart disease. However, clopidogrel does not have the same effect on all patients. In some patients, clopidogrel therapy was followed with adverse events. This can partly be explained by the decreased antiplatelet capacity of clopidogrel. An in vitro study defined this phenomenon as non-responsive or resistant to clopidogrel. However, neither epidemiological data nor the relevance of coronary heart disease risk are clear. Now clopidogrel resistance definition, impact factor, clinical significance and solutions to the ways and problems are reviewed.