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以4-戊烯酸及(R)-4-苯基-2-噁唑烷酮为起始原料,以氯化镁在三乙胺和三甲基氯化硅存在下催化的(R)-4-苯基-3-戊烯酰基-2-噁唑烷酮的埃文斯(Evans)反式羟醛缩合反应为关键步骤,经9步反应合成了(-)-7(R)-羟罗汉脂素,其光谱数据与文献报道的天然产物一致.
Starting from 4-pentenoic acid and (R) -4-phenyl-2-oxazolidinone with (R) -4- Phenyl-3-pentenoyl-2-oxazolidinone as the key step, the synthesis of (-) - 7 (R) Its spectral data is consistent with the natural products reported in the literature.