作者曾报道印度尼西亚半岛地区的居民常有血红蛋白E,而且大多为葡萄糖-6-磷酸脱氢酶缺乏者,其中28%的病例患有钩虫病。这些因素常造成慢性贫血伴有红细胞大小和形态的异常,而这些红细胞的变化又可能影响恶性疟原虫及其宿主细胞的代谢作用,并有可能影响原虫对抗疟药的敏感性。已观察到贫血小鼠体内对氯喹敏感的疟 The authors have reported that residents of the Indonesian Peninsula often have hemoglobin E, and most are glucose-6-phosphate dehydrogenase deficiency, of which 28% of cases suffer from hookworm disease. These factors often result in chronic anemia associated with abnormalities in erythrocyte size and morphology, which in turn may affect the metabolism of P. falciparum and its host cells and may affect the parasite’s sensitivity to antimalarial drugs. Chlormequine-sensitive malaria has been observed in anemic mice