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目的探讨甲氨蝶呤联合米非司酮治疗异位妊娠的临床效果。方法 84例异位妊娠患者按照随机、自愿的原则分为对照组和观察组,每组42例。对照组患者给予甲氨蝶呤治疗,观察组患者给予甲氨蝶呤联合米非司酮治疗,疗程均为2周。比较两组患者治疗后血β-人绒毛膜促性腺激素(β-HCG)值恢复正常时间、包块消失时间和临床效果。结果观察组患者总有效率明显高于对照组,差异有统计学意义(92.9%VS 71.4%,χ2=7.468,P=0.029)。观察组患者血清β-HCG恢复正常时间和包块消失时间据明显小于对照组患者,差异均有统计学意义(均P<0.05)。结论甲氨蝶呤联合米非司酮治疗异位妊娠患者的临床效果显著,可以有效加快患者康复,值得在临床推广应用。
Objective To investigate the clinical effect of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. Methods Eighty-four patients with ectopic pregnancy were divided into control group and observation group according to random and voluntary principles, with 42 cases in each group. Patients in the control group were treated with methotrexate, and patients in the observation group were treated with methotrexate and mifepristone for two weeks. The blood β-HCG values returned to normal, the disappearance of mass and the clinical effect were compared between the two groups after treatment. Results The total effective rate of the observation group was significantly higher than that of the control group (92.9% VS 71.4%, χ2 = 7.468, P = 0.029). The observation group patients serum β-HCG recovery time and mass disappearance of the time was significantly less than the control group, the difference was statistically significant (P <0.05). Conclusion Methotrexate combined with mifepristone in the treatment of ectopic pregnancy patients with significant clinical results, can effectively speed up the rehabilitation of patients, it is worth in the clinical application.