论文部分内容阅读
Coyne(1977)报道,在鼠肠中增加胆汁酸的水平,随着环腺苷酸刺激的增加,同时也引起分泌的增加。为了研究小鼠模型中胆汁对霍乱弧菌和大肠杆菌热不稳定肠毒素诱导小肠过量分泌的作用,作者用6～12周龄C57B1/6J(H-2b)雌性小鼠,通过结扎总胆管以减少肠内的胆汁,来研究肠毒素引起的液体分泌效应。结果发现肠毒素诱导的小肠分泌,空肠比回肠明显。结扎总胆管后24小时,小肠液体的分泌被抑制。结扎后2小时,就观察到轻微的分泌抑制。直至总胆管结扎48小时,
Coyne (1977) reported that increasing levels of bile acids in murine intestine also resulted in increased secretion as cyclic adenosine monophosphate stimulated. In order to investigate the role of bile in the mouse model on the induction of intestinal excretion by Vibrio cholerae and Escherichia coli heat labile enterotoxin, we used C57B1 / 6J (H-2b) female mice, aged 6-12 weeks, by ligation of the common bile duct Reduce the intestinal bile, to study the liquid toxin-induced secretion effect. The results showed that enterotoxin-induced intestinal secretion, jejunum than ileum significantly. Twenty-four hours after ligation of the common bile duct, the secretion of small intestine fluid was inhibited. Two hours after ligation, a slight inhibition of secretion was observed. Until the total bile duct ligation 48 hours,