论文部分内容阅读
目的临床探究在治疗慢性肾脏病合并糖尿病老年患者时,应用前列地尔药物的可行性、优越性。方法选取新乡市第二人民医院2015年3月—2016年3月期间64例因慢性肾病并糖尿病入院治疗的老年患者,按挂号单双数分为两组包括对照组、治疗组,每组32例。对照组行对症治疗,治疗组在此基础上加用前列地尔,观察症状改善情况,统计用药期间患者不良反应情况,同时对患者肾功能恢复情况进行评估。结果治疗后治疗组患者症状改善有效率为90.6%,对照组为78.1%,治疗组较对照组临床病症改善情况好,P<0.05;治疗前各组指标差异无意义,P>0.05用药后对照组较治疗组患者血清肌酐、尿蛋白含量改善效果差,P<0.05;对照组不良反应发生率为15.6%,治疗组为6.3%,治疗组较对照组患者用药不良反应少、用药安全性高,P<0.05。结论临床将前列地尔用于糖尿病肾病治疗,能有效疏通血管、促进血液循环恢复,降低尿蛋白含量,患者恢复效果好且用药安全性高。
Objective To investigate the feasibility and superiority of alprostadil in the treatment of elderly patients with chronic kidney disease and diabetes mellitus. Methods Sixty-four elderly patients admitted to the Second People’s Hospital of Xinxiang City from March 2015 to March 2016 were randomly divided into two groups: control group, treatment group, 32 patients in each group example. Patients in the control group were treated symptomatically. The treatment group was given alprostadil on this basis to observe the improvement of the symptoms and to count the patients ’adverse reactions during the medication period. At the same time, the patients’ renal function recovery was evaluated. Results After treatment, the effective rate of symptom improvement was 90.6% in the treatment group and 78.1% in the control group, and the improvement of clinical symptoms in the treatment group was better than that in the control group (P <0.05). Before the treatment, there was no significant difference in the index of each group, P> 0.05 Compared with the treatment group, the serum creatinine and urinary protein in the treatment group had a poor effect of improving the serum creatinine and urinary protein levels, P <0.05; the incidence of adverse reactions in the control group was 15.6% and in the treatment group was 6.3%; the treatment group had less adverse drug reactions and medication safety , P <0.05. Conclusion The clinical application of alprostadil for the treatment of diabetic nephropathy, can effectively clear the blood vessels, promote blood circulation and reduce urinary protein content, patients with good recovery and medication safety.