论文部分内容阅读
目的研究环氧合酶-2(cyclooxygenase-2,COX-2)和人乳头瘤病毒16型E6蛋白(human papillomavirus-16 E6 protein,HPV16-E6)在宫颈癌中的表达及其与临床病理特征之间的关系。方法采用免疫组化S-P法检测COX-2和HPV16-E6蛋白在宫颈癌上皮中的阳性表达情况。结果COX-2与淋巴结转移、宫旁或脉管浸润及肌层浸润深度呈显著性相关(P<0.05)。HPV16-E6与年龄、病理类型、宫旁或脉管浸润呈显著性相关(P<0.05)。COX-2和HPV16-E6蛋白在宫颈癌中的阳性率呈正相关(rs=0.6014,P<0.01)。结论COX-2和HPV16-E6在宫颈癌的侵袭转移中可能发挥协同作用。联合应用选择性COX-2抑制剂和HPV疫苗是宫颈癌防治中的一个新的有效策略。
Objective To investigate the expression of cyclooxygenase-2 (COX-2) and human papillomavirus-16 E6 protein (HPV16-E6) in cervical cancer and their relationship with clinicopathological features The relationship between. Methods The positive expression of COX-2 and HPV16-E6 in cervical cancer epithelium was detected by immunohistochemical S-P method. Results There was a significant correlation between COX-2 and lymph node metastasis, uterine or vascular invasion and depth of myometrial invasion (P <0.05). HPV16-E6 was significantly associated with age, pathological type, uterine or vascular infiltration (P <0.05). The positive rates of COX-2 and HPV16-E6 in cervical cancer were positively correlated (rs = 0.6014, P <0.01). Conclusions COX-2 and HPV16-E6 may play synergistic roles in the invasion and metastasis of cervical cancer. The combination of selective COX-2 inhibitors and HPV vaccine is a new effective strategy in the prevention and treatment of cervical cancer.