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目的观察通心方对冠心病三支血管病变患者心室重构的临床疗效及对心血管事件的影响。方法入选患者随机分为两组,治疗组在基础治疗基础上给予通心方,对照组仅给予基础治疗,疗程6个月;分别于治疗前后观察左室舒张末期容积指数(LVEDVI)、左室收缩末期容积指数(LVESVI)、射血分数(EF)、E峰/A峰比值(E/A)、室壁厚度(WT)、左室重量指数(LVMI)和室壁运动指数(WMI)的变化,并随访1年内心血管事件发生情况。结果治疗组治疗后LVEDVI下降,LVMI下降,WMI下降;对照组治疗后E/A比值降低、LVMI升高,较治疗组变化明显;其治疗后WMI明显升高。两组随访1年,心血管事件发生率近似。结论通心方能改善冠心病三支病变患者的心室重构和心室的舒张功能,对1年内心血管事件无明显影响。
Objective To observe the effect of Tongxin Recipe on ventricular remodeling in patients with coronary artery disease and its effect on cardiovascular events. Methods The selected patients were randomly divided into two groups. The treatment group was given Tongxin Fang on the basis of basic treatment. The control group was given only basic treatment for 6 months. Left ventricular end-diastolic volume index (LVEDVI), left ventricular Changes of LVESVI, EF, E / A, WT, LVMI and WMI , And follow-up within 1 year of cardiovascular events. Results After treatment, LVEDVI decreased, LVMI decreased and WMI decreased. E / A ratio decreased and LVMI increased in control group after treatment, which was more obvious than that in treatment group. WMI increased obviously after treatment. Two years follow-up of 1 year, the incidence of cardiovascular events is similar. Conclusion Tongxin Recipe can improve ventricular remodeling and ventricular diastolic function in patients with three lesions of coronary heart disease, and have no significant effect on cardiovascular events in one year.