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目的 :分析叶酸联合利巴韦林在小儿轮状病毒性肠炎治疗中的应用价值。方法 :以2014年3月~2015年8月在我院接受治疗的轮状病毒性肠炎患儿为观察对象。根据其治疗方式分为利巴韦林组(45例)和联合用药组(50例)。观察两组患儿的治疗效果,比较两组患儿治疗前后症状体征改善情况及生活质量的差异。结果 :联合用药组治疗的有效率明显高于利巴韦林组,差异具有统计学意义;联合用药组腹泻、发热、呕吐和腹胀等临床症状消失的例数明显较利巴韦林组多,差异具有统计学意义;两组患儿治疗前躯体功能、躯体角色和肢体疼痛等生活质量得分无明显差别,治疗后,两组患儿的上述指标均较治疗前升高,且联合用药组升高更明显。结论 :叶酸联合利巴韦林对轮状病毒性肠炎患儿有较好的治疗效果,可明显改善患儿的临床症状,提高其生活质量。
Objective: To analyze the value of folic acid combined with ribavirin in the treatment of pediatric rotavirus enteritis. Methods: From March 2014 to August 2015 in our hospital for treatment of children with rotavirus enteritis were observed. Divided into ribavirin group (45 cases) and combination group (50 cases) according to the way of treatment. The therapeutic effect of two groups of children was observed. The improvement of symptoms and signs and quality of life before and after treatment were compared between the two groups. Results: The effective rate of combination therapy group was significantly higher than that of ribavirin group, the difference was statistically significant. The number of clinical symptoms such as diarrhea, fever, vomiting and abdominal distension disappeared in combination group was significantly more than that in ribavirin group, The difference was statistically significant. There was no significant difference in QOL scores between the two groups in terms of body function, body function and limb pain. After treatment, the above indexes in both groups were higher than those before treatment, Clementine obvious. Conclusion: Folic acid combined with ribavirin has a good therapeutic effect on children with rotavirus enteritis and can significantly improve the clinical symptoms and improve the quality of life in children.