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目的 探讨妊娠期糖尿病(GDM)患者血清同型半胱氨酸(Hcy)含量与糖脂代谢水平的相关关系.方法 收集2016年9-12月间该院收治的GDM患者90例作为GDM组,另选取同期在该院进行产检的糖耐量正常孕妇50例作为对照组.入院后检测两组孕妇血清中Hcy含量,外周血中糖代谢、脂质代谢相关指标水平,采用Pearson检验评价GDM孕妇血清Hcy含量与糖脂代谢异常程度的相关关系.结果 GDM组孕妇血清中Hcy的含量显著高于对照组孕妇(P＜0.05).GDM组孕妇的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)水平均显著高于对照组孕妇(均P＜0.05),甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平显著高于对照组孕妇(均P＜0.05),高密度脂蛋白胆固醇(HDL-C)水平显著低于对照组孕妇(P＜0.05).经Pearson检验发现,GDM孕妇血清中Hcy含量与FBG、HbA1c、FINS、TG、TC、LDL-C水平呈正相关关系,与HDL-C呈负相关关系(P＜0.05).结论 GDM孕妇血清Hcy含量高于正常孕妇,且Hcy含量与糖脂代谢异常程度具有正相关关系.“,”Objective To explore the correlation between serum Hcy level and glucose and lipid metabolism in patients with gestational diabetes mellitus (GDM).Methods Ninety patients with GDM treated in the Third Hospital of PLA from September to December in 2016 were selected as GDM group,and fifty patients with normal glucose tolerance and receiving prenatal examiantion in the hospital during the same period were selected as control group.After admission to the hospital,the levels of serum Hcy,related indexes of glucose and lipid metabolism in peripheral blood of cases in the two groups were detected,Pearson test was used to evaluate the correlation between serum Hcy level and abnormal degrees of glucose and lipid metabolism.Results The level of serum Hcy in GDM group was statistically significantly higher than that in control group (P＜0.05).The levels of fasting blood glucose (FBG),glycosylated hemoglobin (HbA1c),and fasting insulin (FINS) in GDM group were statistically significantly higher than those in control group (P＜0.05).The levels of triglyceride (TG),total cholesterol (TC),and low-density lipoprotein cholesterin (LDL-C) in GDM group were statistically significantly higher than those in control group (P＜0.05).The level of high-density lipoprotein cholesterin (HDL-C) in GDM group was statistically significantly lower than that in control group (P＜0.05).Pearson test showed that the level of serum Hcy in GDM patients was positively correlated with the levels of FBG,HbA1 c,FINS,TG,TC,and LDL-C,which was negatively correlated with the level of HDL-C (P＜0.05).Conclusion The level of serum Hcy in GDM patients is higher than that in normal pregnant women,which is positively correlated with abnormal degrees of glucose and lipid metabolism.