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四氢噻唑-2-硫酮(tetrahydrothiazole-2-thione,简称TTT)与N-保护氨基酸反应得到了一氨酰基四氢噻唑-2-硫酮衍生物并作为活泼酰胺用于肽的合成,当用此法合成肽时,曾利用二价铜离子与TTT具有很强络合能力这一特性,反应后用二价铜盐可除去反应中生成的TTT。另外还可用TTT分解侧链官能团被保护的氨基酸铜络合物。在上述两类反应中均生成TTT铜络合物。关于TTT铜络合物的晶体结构尚未见文献报道,本文将报道该络合物的品体与分子结构,以便时TTT与二价铜离子络合反应的深入了解以及进一步开发TTT铜络合物新反应提供结构数据。
The reaction of tetrahydrothiazole-2-thione (TTT) with N-protected amino acid affords a mono-acyltetrahydrothiazole-2-thione derivative and is used as a living amide in peptide synthesis. When this method is used to synthesize peptides, the characteristic of strong biocompatibility of divalent copper ions and TTT has been used. After the reaction, the divalent copper salts can be used to remove the TTT generated in the reaction. TTT can also be used to decompose the side chain functional groups are protected amino acid copper complexes. TTT copper complexes are formed in both types of reactions. The crystal structure of TTT copper complex has not been reported yet. In this paper, we will report on the structure and molecular structure of this complex in order to gain a better understanding of the TTT complex reaction with divalent copper ions and to further develop the TTT copper complex The new reaction provides structural data.