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探讨血清和滑液中骨形态发生蛋白-2(BMP-2)表达水平与骨关节炎(OA)患者KL分级及骨关节炎疾病活动指数临床评估(WOMAC)评分的相关性.[方法]以50例OA患者为观察组,随机挑选50例健康人群为对照组,检测OA患者血清及滑液和健康人群血清中的BMP-2蛋白的表达水平.分析OA患者BMP-2蛋白的表达水平与KL分级及WOMAC评分的相关性.[结果]OA患者血清中BMP-2蛋白表达水平明显高于对照组(P<0.05).在不同KL分级亚组之间,随着KL分级的增加,OA患者血清及滑液中BMP-2蛋白的表达水平不断提高(P<0.05).同时在OA患者以及同一KL分级患者中,滑液中的BMP-2表达水平明显高于血清(P<0.05).OA患者血清及滑液中的BMP-2蛋白表达水平与OAKL分级及WOMAC评分均呈正相关.[结论]OA患者血清及滑液中BMP-2的蛋白表达水平明显高于健康人群,且随着KL分级的增加,其血清及滑液中BMP-2的蛋白表达水平逐渐升高,OA患者血清及滑液中BMP-2的蛋白表达水平与KL分级及WOMAC均呈正相关性,可能对OA疾病严重程度的评价有一定价值.“,”Toinvestigatethecorrelationbetweentheexpressionofbonemorphogeneticprotein-2(BMP-2)in serumandsynovialfluidandKLgradeandclinicalevaluationofosteoarthritisdiseaseactivityindex (WOMAC)scoreinpa-tientswithosteoarthritis(OA).[Methods]FiftypatientswithOAwereselectedastheobservationgroupand50healthypeople wererandomlyselectedasthecontrolgroup.TheexpressionofBMP-2proteininserumandsynovialfluidofOApatientsand serumofhealthypeoplewasdetectedsoastoanalyzethecorrelationbetweenBMP-2proteinexpressioninserumandsynovial fluidofpatientswithOAandKLgradeandWOMACscore.[Results]TheexpressionlevelofBMP-2proteininserumofOA patientswassignificantlyhigherthanthatofhealthypeople(P<0.05).TheexpressionofBMP-2proteininserumandsyno-vialfluidofOApatientsincreasedwiththeincreaseofKLclassificationamongdifferentKLclassificationsubgroups(P<0. 05).Atthesametime,BMP-2expressioninsynovialfluidwassignificantlyhigherthanthatinseruminpatientswithOAand thesameKLgrade(P<0.05).TheexpressionofBMP-2proteininserumandsynovialfluidofpatientswithOAwasposi-tivelycorrelatedwithOA KLgradeand WOMACscore.[Conclusion]TheexpressionlevelofBMP-2inserumandsynovial fluidofOApatientsissignificantlyhigherthanthatofhealthypeople,andwiththeincreaseofKLclassification,theexpres-sionlevelofBMP-2inserumandsynovialfluidincreasegradually.TheexpressionlevelofBMP-2inserumandsynovialfluid ofpatientswithOA waspositivelycorrelatedwithKLgradeandWOMAC,whichmaybevaluableinevaluatingtheseverity ofOA.