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目的探讨宫颈癌新辅助化疗后手术切除组织病理学变化。方法 51例宫颈癌患者,给予新辅助化疗与手术切除术治疗,评估其治疗效果以及切除组织病理学变化。结果 (1)本组51例患者治疗总有效率为88.24%;(2)新辅助化疗后平均肿瘤直径(3.01±0.19)cm,血管内皮生长因子VEGF阳性率为23.53%,明显小于新辅助化疗前的(5.26±0.57)cm、68.63%(P<0.05)。结论宫颈癌患者行手术切除治疗前实施新辅助化疗的临床效果显著,其血管内皮生长因子阳性率明显降低,值得推广。
Objective To investigate the histopathological changes of surgical resection after neoadjuvant chemotherapy for cervical cancer. Methods Fifty-one patients with cervical cancer were treated with neoadjuvant chemotherapy and surgical resection, and their therapeutic effects and histopathological changes were evaluated. Results (1) The total effective rate of the 51 patients in this group was 88.24%. (2) The mean tumor diameter after neoadjuvant chemotherapy was (3.01 ± 0.19) cm and the positive rate of vascular endothelial growth factor VEGF was 23.53%, which was significantly lower than that of neoadjuvant chemotherapy Before (5.26 ± 0.57) cm, 68.63% (P <0.05). Conclusion The clinical effect of neoadjuvant chemotherapy before surgical resection is obvious in patients with cervical cancer, and the positive rate of VEGF is significantly reduced, which deserves promotion.