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Ⅰ . IntroductionCO2-breath tests with 14C or 13C labeled compounds have been shown to be useful or potentially useful in the diagnosis of several importam diseases. Based on the fact that the hepatic microsomal mixed function oxidase can metabolize many drugs through N- or O-demethylation, aminopyrine labeled with 14C or 13C at the N-methyl position have been applied to patients with liver diseases, and a slow down of demethylation as indicated by the decrease of labeled CO2 in exhaled air has been shown to occur in patients with liver cirrhosis.Since the aminopyrine breath test suffers from the possibility, though infrequent, of
I. Introduction CO2-breath tests with 14C or 13C labeled compounds have been shown to be useful or potentially useful in the diagnosis of several importam diseases. Based on the fact that the hepatic microsomal mixed function oxidase can metabolize many drugs through N- or O- demethylation, aminopyrine labeled with 14C or 13C at the N-methyl position have been applied to patients with liver diseases, and a slow down of demethylation as indicated by the decrease of labeled CO2 in exhaled air has been shown to occur in patients with liver cirrhosis .Since the aminopyrine breath test suffers from the possibility, though infrequent, of