Objective To review and analyze the surgical results of arterial switch operations in complete D-transposition of the great arteries (TGA ). Methods A total of 113 patients underwent arterial switch operation from Jan. 2001 to Dec. 2005. There were 60 patients with transposition of the great arteries and intact ventricular septum (TGA/IVS) and 53 patients with transposition of the great arteries and ventricular septal defect (TGA/VSD). The lowest body weight was 2.3 kg and the smallest age was 6 h. The arterial switch operation was performed under deep hypothermia with circulatory arrest and low-flow perfusion. Results The total mortality was 9.73%. There were 5 deaths in TGA/IVS (8.3%), 6 deaths in TGA/VSD (11.3%). With the development of surgical technique, peri-operative management and cardiopulmonary bypass, the total mortality significantly decreased from 16.65% in the early times to 5.5% lately. Conclusion The vital risk of the operation is coronary artery malformation. The incidence of coronary artery malformation is higher in TGA/VSD than in TGA/ IVS. The positional relationship of the great arteries does not affect the results of the operation. The arterial switch operation should be prevented when the pressure ratio between the left and right ventricle is less than 0.6, otherwise it is great likely to cause severe low cardiac output postoperatively.