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目的了解1 022例腹泻患儿沙门菌感染的流行病学特征、菌型分布及耐药情况。方法对在顺德地区2所医院就诊的小儿腹泻患者进行沙门菌分离及药敏试验,并开展流行病学调查。结果从1 022例患儿中,分离出沙门菌56株,阳性率为5.5%。分离出多种血清型,其中斯坦利沙门菌17株(30.4%),鼠伤寒沙门菌15株(26.8%),肠炎沙门菌6株(10.7%)。分离出的沙门菌除对头孢他啶、头孢噻肟、头孢吡肟的耐药性较低外,对环丙沙星、氯霉素、庆大霉素、甲氧苄啶/磺胺甲噁唑、链霉素、氨苄西林、萘啶酸及四环素的耐药较为严重。小儿沙门菌腹泻主要集中在5-9月份发病,以2岁以下婴幼儿为主(67.9%),症状以胃肠道症状为主,大便性状多有改变,部分合并轮状病毒和/或腺病毒感染。结论顺德小儿沙门菌感染性腹泻以2岁以下婴幼儿居多,多发生于夏秋季,以斯坦利沙门菌、鼠伤寒沙门菌和肠炎沙门菌感染为主,并对多种抗生素具较高耐药性。
Objective To investigate the epidemiological characteristics, bacterial distribution and drug resistance of Salmonella in 1022 children with diarrhea. Methods Salmonella isolation and drug susceptibility tests were performed on pediatric patients with diarrhea in two hospitals in Shunde and the epidemiological investigation was carried out. Results From 1022 children, 56 strains of Salmonella were isolated, the positive rate was 5.5%. Among them, 17 strains of Salmonella Stanis (30.4%), 15 strains of Salmonella typhimurium (26.8%) and 6 strains of Salmonella enteritidis (10.7%) were isolated. Isolated Salmonella in addition to ceftazidime, cefotaxime, cefepime resistance is low, the ciprofloxacin, chloramphenicol, gentamicin, trimethoprim / sulfamethoxazole, chain Amycin, ampicillin, nalidixic acid and tetracycline resistance is more serious. Pediatric salmonella diarrhea mainly occurred in May-September, mainly in infants under 2 years old (67.9%). Symptoms were mainly gastrointestinal symptoms, with many changes in stool characteristics, and some were combined with rotavirus and / or gland Viral infection. Conclusions Salmonella enteritidis in Shunde is mainly infants under 2 years of age, mostly occurring in summer and autumn, with Salmonella stannii, Salmonella typhimurium and Salmonella enteritidis infection as the main, and a variety of antibiotics with high resistance Sex.