慢性乙型肝炎 ( CHB)的发病机理十分复杂 ,迄今尚未完全阐明 ,但机体的免疫状态与乙肝的病理损害有很大关系〔1,2〕已被许多学者公认。由于免疫功能低下 ,不能彻底清除肝细胞内病毒 ,导致 HBV持续感染。 1 972年 ,Dudley等认为细胞免疫的缺陷或功能不足 ,是导致慢性感染的主要? The pathogenesis of chronic hepatitis B (CHB) is very complicated and has not yet been fully elucidated, but the immune status of the body has a great relationship with the pathological damage of hepatitis B [1,2]. It has been recognized by many scholars. Due to the immunocompromised, can not completely remove the virus within the liver cells, leading to persistent HBV infection. In 1972, Dudley et al. Concluded that the deficiency or deficiency of cellular immunity is the main cause of chronic infection.