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目的:研究肾透明细胞癌组织中微血管相关蛋白1轻链3(MAP1-LC3)的表达,探讨其与肾癌生物学行为的关系。方法:采用免疫组织化学SP方法检测45例肾透明细胞癌及10例正常肾组织中MAP1-LC3的表达情况。结果:45例肾透明细胞癌组织中,37例MAP1-LC3表达阳性(82.2%),与正常肾组织(40.0%)比较,其表达差异有统计学意义(P<0.05)。结论:MAP1-LC3在肾癌组织中表达增强,这种高表达可能与肾癌的发生发展有关。
Objective: To investigate the expression of MAP1-LC3 in renal clear cell carcinoma and its relationship with the biological behavior of renal cell carcinoma. Methods: Immunohistochemical SP method was used to detect the expression of MAP1-LC3 in 45 cases of clear cell renal cell carcinoma and 10 cases of normal renal tissues. Results: Among the 45 cases of renal clear cell carcinoma, the expression of MAP1-LC3 was positive in 37 cases (82.2%). Compared with the normal kidney tissue (40.0%), the expression of MAP1-LC3 was significantly different (P <0.05). Conclusion: The expression of MAP1-LC3 in renal cell carcinoma increased, which may be related to the occurrence and development of renal cell carcinoma.