自胰岛素首次用于治疗糖尿病以来,随着对糖尿病病理生理和发病机制认识的深入,胰岛素的应用越来越广泛。综述近年来相关文献中有关胰岛素及其类似物制剂的分类、给药途径、体内吸收代谢、临床应用和不良反应等方面内容,为进一步研究、开发和合理利用胰岛素及其类似物提供参考。 Since insulin was first used to treat diabetes mellitus, insulin has become more and more popular with the increasing understanding of pathophysiology and pathogenesis of diabetes. This review summarizes the classification, administration route, absorption and metabolism in vivo, clinical application and adverse reactions of insulin and its analogs in related literatures in recent years. It provides a reference for further research, development and rational use of insulin and its analogues.