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氨苄青霉素常用于治疗尿路感染。Fab-re,J和Whelton,A等曾分别研究了在正常的大鼠和非病态人肾中氨苄青霉素的分布。但是,氨苄青霉素在急性感染的肾内分布尚无资料。为此,作者在正常的和肾盂肾炎的大鼠中对照了肾皮质、肾髓质和肾乳头以及血清和尿中氨苄青霉的分布。整个实验使用了200～240克重的雌性大鼠,用大肠杆菌作为接种物,采用两种髓质接种法制造肾盂肾炎模型。接种后第四天,即产生严重肾盂肾炎(广泛的炎症,并形成脓肿)时,开始治疗。选择两种给药方式:100
Ampicillin is commonly used to treat urinary tract infections. Fab-re, J and Whelton, A, et al. Have investigated the distribution of ampicillin in normal rats and non-diseased human kidneys, respectively. However, the distribution of ampicillin in the kidney of acute infection is not available. For this reason, the authors compared the distribution of ampicillin in the renal cortex, renal medulla and renal papilla, as well as in serum and urine, in normal and pyelonephritis rats. The entire experiment used 200 to 240 grams of female rats, using E. coli as an inoculum and two medulla inoculations to make a pyelonephritis model. On the fourth day after inoculation, ie, with severe pyelonephritis (extensive inflammation and abscess formation), treatment begins. Choose two methods of administration: 100