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自从Sekieuchi和obi在1961年开展了固体分散体工作以来,应用固体分散体这一手段来提高难溶性药物的溶出速率及生物利用度引起了药剂学工作者的浓厚兴趣。分子量在1000～8000范围内的PEG是用于这种目的最常用的载体。然而,在单独聚乙二醇(PEG)作载体的处方中,难溶性药物的溶出可能会很慢或不完全。这是由于难溶性药物会在颗粒表面形成吸附层,阻碍了颗粒的溶蚀;或者一旦载体溶解后,药物颗粒又
Since Sekieuchi and OBI began working on solid dispersions in 1961, the use of solid dispersions as a means to increase the dissolution rate and bioavailability of poorly soluble drugs has drawn the interest of chemists. PEG with a molecular weight in the range of 1000-8000 is the most commonly used carrier for this purpose. However, the dissolution of poorly soluble drugs can be slow or incomplete in the formulation of polyethylene glycol (PEG) alone. This is due to poorly soluble drugs in the particle surface adsorption layer, hinder the erosion of particles; or once the carrier is dissolved, the drug particles and