目的 探讨非对称二甲基精氨酸(ADMA)水平与血管再狭窄的关系.方法 检索PubMed、Embase、Web of Science、SinoMed、中国知网、万方等中英文数据库中关于ADMA水平与患者血管再狭窄的病例对照研究,按照纳入排除标准筛选文献,采用Stata 12.0软件进行Meta分析.结果 最终共纳入8项研究,Meta分析结果显示,血管再狭窄患者ADMA水平较对照组显著升高(SMD 1.21;95％CI 1.03～1.39);根据ADMA检测方法进行亚组分析,发现HPLC法检测组中同质性高(I2=0.00％;P=0.53),但ELISA法检测组异质性仍十分显著(I2=94.80％;P<0.01).Begg\'s检验及Egger\'s检验提示无发表偏倚.结论 血管再狭窄患者ADMA水平显著升高,ADMA可作为监测血管再狭窄的候选生物标志物;HPLC法较ELISA法更适用于ADMA检测.“,”Objective To investigate the association of asymmetric dimethylarginine (ADMA) with restenosis via Meta-analysis. Methods Relevant studies were searched using databases. Standardized mean difference ( SMD) with 95％ confidence intervals ( CI) was used to summarize the difference in ADMA level between rest-enosis and control group. Subgroup analysis and sensitivity analysis were performed to dissect the heterogeneity. Publication bias was assessed using Begg\'s funnel plot and Egger\'s regression asymmetry tests. Results A total of 8 case-control studies was included in this Meta-analysis. Pooled analysis showed that ADMA level was significantly higher in restenosis patients compared with that in the controls ( SMD 1 . 21;95％ CI 1 . 03-1 . 39 ) in a random effect model. The heterogeneity of the subgroup analysis for HPLC disappeared (I2 =0. 00％; P =0. 53),but high heterogeneity persisted in testing studies using ELISA (I2 =94. 80％;P<0. 01). There was no evidence of publication bias as determined by Begg\'s and Egger\'s tests in the Meta-analysis. Conclusion Meta-analysis demon-strates that the increased circulating ADMA levels could be a useful prognostic biomarker for restenosis after re-vascularization. HPLC is preferable method for ADMA measurement instead of ELISA.