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目的探讨急性脑梗死应用法舒地尔治疗前后血C-反应蛋白(CRP)、血浆纤维蛋白原(FIB)水平的变化及意义。方法统计分析2011年至2013年淅川县人民医院神经内科收治的100例急性脑梗死患者的临床资料。结果治疗前两组患者的神经功能缺损程度评分及ADL评分之间比较差异均无统计学意义(P>0.05);治疗后观察组患者的神经功能缺损程度评分及ADL评分均明显比对照组低(P<0.05);观察组患者的痊愈率(28%)、治疗总有效率(88%)均比对照组(12%、72%)高(P<0.05),但两组病死率比较差异无统计学意义(P>0.05);治疗前两组患者的血CRP、FIB水平之间比较差异均无统计学意义(P>0.05);治疗后观察组患者的血CRP、FIB水平均明显比对照组低(P<0.05);两组患者治疗前后TESS评分比较差异均无统计学意义(P>0.05)。结论急性脑梗死应用法舒地尔能够有效降低患者的血CRP、FIB水平,从而有效改善患者的临床症状及预后,值得推广。
Objective To investigate the changes of serum C-reactive protein (CRP) and fibrinogen (FIB) in patients with acute cerebral infarction before and after fasudil treatment. Methods The clinical data of 100 patients with acute cerebral infarction admitted to the Department of Neurology, Xichuan Hospital of People ’s Hospital from 2011 to 2013 were statistically analyzed. Results There was no significant difference between the two groups before treatment and the ADL score (P> 0.05). After treatment, the score of neurological deficit and the ADL score in the observation group were significantly lower than those in the control group (P <0.05). The cure rate (28%) and total effective rate (88%) in the observation group were significantly higher than those in the control group (12% and 72%, P < (P> 0.05). There was no significant difference in blood CRP and FIB levels between the two groups before treatment (P> 0.05). After treatment, the blood levels of CRP and FIB in the observation group were significantly higher than those in the control group The control group was lower (P <0.05). There was no significant difference in TESS scores between the two groups before and after treatment (P> 0.05). Conclusion The application of fasudil in acute cerebral infarction can effectively reduce the blood levels of CRP and FIB in patients with acute cerebral infarction, thus effectively improving the clinical symptoms and prognosis of patients.