先兆子痫是妊娠20周后以高血压和蛋白尿或单纯水肿为表现的常见妊娠合并症。内皮细胞功能障碍伴血管痉挛、病理性凝血和对加压物质的过敏性为其主要病理学特征。严重者可引起肾衰、肝功能障碍、心衰及呼衰,甚至死亡。 虽经半个多世纪的集中研究,先兆子痫仍是母儿主要死亡原因。特别在围产保健和医疗条件较差的地区,母儿并发症及病死牢仍很高。近年来国立卫生研究所网络妇儿组的研究显示,小剂量阿斯匹林仅对未产健康孕妇收缩压初始升高者稍有预防作 Preeclampsia is a common pregnancy complication manifested by hypertension and proteinuria or simple edema after 20 weeks of gestation. Endothelial dysfunction with vasospasm, pathological coagulation and allergy to pressurized substances are its major pathological features. Severe cases can cause renal failure, liver dysfunction, heart failure and respiratory failure, and even death. Although more than half a century of concentrated study, preeclampsia is still the leading cause of maternal death. Especially in areas where perinatal health care and medical conditions are poor, maternal and child complications and deaths remain high. In recent years, the National Institutes of Health network of women and children group studies show that low-dose aspirin only unhealthy pregnant women, the initial rise in systolic blood pressure was slightly preventive