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目的 :动态观察脑出血患者血浆神经肽Y(NPY)、神经降压素 (NT)和胃动素 (MTL)的水平变化 ,探讨其临床意义。方法 :采用放射免疫方法测定了 4 6例脑出血患者及 2 8例健康成人血浆NPY、NT及MTL的含量。结果 :脑出血患者血浆NPY、NT及MTL水平均明显高于对照组 (P <0 .0 0 1,P <0 .0 1,P<0 .0 1)。发病 2 4h内即显著升高 ,NPY在 4～ 7d、NT和MTL在 1～ 3d达高峰 ,8～ 15d三者均开始下降 ,15d后仍在较高水平。重症患者NPY水平显著高于轻型和中型 ,中、重型患者NT水平显著高于轻型。大面积出血NPY、NT及MTL水平均高于小面积出血。伴发病积分≥ 6分者高于积分 <6分者。伴上消化道出血者显著高于不伴上消化道出血者。结论 :NPY、NT及MTL参与了脑出血的发生及病理生理过程。
Objective: To observe the changes of plasma neuropeptide Y (NPY), neurotensin (NT) and motilin (MTL) in patients with cerebral hemorrhage. Methods: The plasma levels of NPY, NT and MTL in 46 patients with cerebral hemorrhage and 28 healthy adults were determined by radioimmunoassay. Results: The levels of plasma NPY, NT and MTL in patients with intracerebral hemorrhage were significantly higher than those in the control group (P <0.01, P <0.01, P <0.01). The incidence of NPY increased significantly within 24 hours. The NPY peaked at 4 ~ 7 days and NT and MTL peaked at 1 ~ 3d. The levels of NPY began to decrease from 8 to 15 days and remained high after 15 days. The severity of NPY in critically ill patients was significantly higher than those in mild and moderate, moderate and severe NT patients. Large area bleeding NPY, NT and MTL levels were higher than a small area of bleeding. Patients with a disease score ≥ 6 were higher than those with a score <6. Patients with upper gastrointestinal bleeding were significantly higher than those without upper gastrointestinal bleeding. Conclusion: NPY, NT and MTL are involved in the occurrence of cerebral hemorrhage and pathophysiological process.