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目的:分析研究高压氧联合甲硝唑治疗复发性口腔溃疡的临床疗效。方法:选取2011年1月-2012年9月到我院就诊的204例复发性口腔溃疡患者,采用随机数字法分为观察组和对照组,每组102例。观察组采取高压氧结合甲硝唑治疗,对照组仅采取口服甲硝唑治疗,跟踪随访2年,比较两组疗效及复发情况。结果:观察组止痛、愈合总有效率为87.26%明显高于对照组的72.55%(P<0.05),观察组的复发情况也明显优于对照组(P<0.05)。结论:高压氧联合甲硝唑治疗复发性口腔溃疡疗效好,有助于减少复发,值得在临床应用中推广。
Objective: To analyze the clinical efficacy of hyperbaric oxygen combined with metronidazole in the treatment of recurrent oral ulcer. Methods: Totally 204 patients with recurrent oral ulcer who visited our hospital from January 2011 to September 2012 were randomly divided into observation group and control group, with 102 cases in each group. The observation group was treated with hyperbaric oxygen combined with metronidazole. The control group was treated with metronidazole alone. The follow-up was 2 years. The curative effect and recurrence of the two groups were compared. Results: The total effective rate of pain relief and healing in the observation group was 87.26%, which was significantly higher than that in the control group (72.55%, P <0.05). The relapse rate in the observation group was also significantly better than that in the control group (P <0.05). Conclusion: Hyperbaric oxygen combined with metronidazole in the treatment of recurrent oral ulcer is effective and can help reduce the recurrence. It is worth to be popularized in clinical application.