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由于在抗肿瘤生物碱Coralyne与致癌诱变的多核碳氢化合物7,12-二甲基苯并〔a〕蒽(DMBA)之间,以及抗肿瘤生物碱两面针碱(Nitidine)与诱变多核碳氢化合物5-甲基(艹屈)之间,它们在结构上的相似性促使人们以DMBA为参照标准,用Ames’histine-auxotroph实验对这些生物硷和与其相关的抗癌类似物的诱变性进行评价.在这些抗肿瘤化合物中未见有致变性,而DMBA则显示有强诱变性.实验结果使人想到也许这些抗肿瘤化合物中季氮原子和占据关键位置上的烃氧基的存在减弱了与其结构相关的多核碳氢化合物的诱变性(也可能是致癌性).
Due to the antitumor alkaloid Coralyne and carcinogenic mutagenicity of polynuclear hydrocarbon 7,12-dimethylbenz [a] anthracene (DMBA), as well as the antitumor alkaloids Nitidine and mutagenic multi-core The structural similarity between the 5-methylhydrocarbons and their structural prominence led to the use of DMBA as a reference standard for the induction of these alkaloids and their associated anti-cancer analogs by the Ames’histine-auxotroph assay Denaturation, no in vitro mutagenesis was observed in these antitumor compounds, and DMBA showed strong mutagenicity The experimental results suggest that perhaps the quaternary nitrogen atoms in these antitumor compounds and occupy the critical oxygen-containing groups There is a weakening of the mutagenicity (and possibly carcinogenicity) of polynuclear hydrocarbons related to their structure.