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作者对干扰素与利巴韦林（病毒唑）联合治疗乙型肝炎的姐妹染色单体交换率（ＳＣＥ）的影响进行了体外试验和临床研究。体外试验结果，与临床用药前的ＳＣＥ比较有明显差异（Ｐ＜０．０５，＜０．０１）而与对照无差异（Ｐ＞０．０５），临床用药后的ＳＣＥ恢复正常，一年随访无变化。从细胞遗传效应角度提示干扰素与利巴韦林治疗乙型肝炎有效，ＳＣＥ可作为乙肝抗病毒治疗药物疗效判断指标。
The authors conducted an in vitro and clinical study of the effects of interferon and ribavirin (ribavirin) in the treatment of hepatitis B in sister chromatid exchange rates (SCE). The result of in vitro test showed significant difference compared with SCE before clinical treatment (P <0.05, <0.01) but no difference with control (P> 0.05). SCE returned to normal after one-year clinical follow-up No change. From the perspective of cytogenetic effect interferon and ribavirin effective treatment of hepatitis B, SCE can be used as indicators of efficacy of hepatitis B antiviral drugs.