目的 :研究甲苯咪唑 β 环糊精包合物的制备方法及包合前后甲苯咪唑物理性质变化。 方法 :采用溶剂法制备甲苯咪唑 β 环糊精包合物 ,于 ( 2 88± 1)nm波长处用紫外分光光度法测定了包合物及甲苯咪唑的溶出速度、溶解度 ,比较了二者的X 射线衍射图谱。结果 :包合后 ,包合物的溶出速度参数T50 为 10 .44min ,甲苯咪唑为 2 2 7.97min。甲苯咪唑的溶解度增大了 5 .6 6倍。甲苯咪唑的晶体衍射峰发生变化。结论 :甲苯咪唑与 β 环糊精形成了新的物相 ,包合后 ,甲苯咪唑的溶解度、溶出速度增强。甲苯咪唑与 β 环糊精确已形成包合物 Objective: To study the preparation of mebendazole β-cyclodextrin inclusion compound and the change of mebendazole physical properties before and after inclusion. Methods: The inclusion compound of mebendazole β-cyclodextrin was prepared by solvent method. The dissolution rate and solubility of inclusion compound and mebendazole were determined by ultraviolet spectrophotometry at the wavelength of (2 88 ± 1) nm X-ray diffraction pattern. Results: The inclusion compound dissolution rate parameter T50 was 10.44min and mebendazole was 2 2 7.97min after inclusion. The solubility of mebendazole increased by 5.66 times. The crystal diffraction peak of mebendazole changed. Conclusion: Mebendazole and β-cyclodextrin form a new phase. After inclusion, the dissolution and dissolution rate of mebendazole increase. Mebendazole and β-cyclodextrin do form an inclusion compound