采用 GC/ MS单离子检测的方法测定了联苯苄唑溶液剂和霜剂在家兔皮肤抹药后的血药浓度和在肝、胃、皮肤等组织中的药物浓度 ;并用 3P87软件对血药浓度进行了拟合 ,估算了药物动力学参数。结果表明 ,溶液剂和霜剂的体内过程均符合二室开放模型 ,Tmax 分别为 2 .88h和 5 .84h,Cmax 分别为35 6 .1 8ng/ ml和 1 82 .81 ng/ ml。在组织联苯苄唑含量测定中 ,只有用药局部皮肤有残留 ,而肝、胃和肌肉等组织中没有联苯苄唑残留。 The plasma concentration of bifonazole solution and cream in the skin of rabbits were determined by GC / MS single ion assay and the drug concentrations in the liver, stomach and skin were measured. Drug concentrations were fitted and pharmacokinetic parameters were estimated. The results showed that the in vivo process of the solutions and creams were in accordance with the two-compartment open model with Tmax of 2.88 h and 5.84 h, respectively, with Cmax of 35 6 .18 ng / ml and 1 82 .81 ng / ml, respectively. In the determination of bifonazole in the tissue, there was only residual skin on the topical side of the drug, while no bifonazole remained on the liver, stomach and muscle tissues.