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自1975年发现内源性阿片(吗啡)样物质(简称内啡素)以来,该领域研究十分活跃,到1982年为止,有关论文已达万篇。国际著名的疼痛研究权威、痛觉闸门控制学说的创始人Melzack和Wall声称,这个时期所取得的成果是整个疼痛与镇痛研究领域中的一次重大突破。但内啡素的意义远不止于这一点,它对整个医学及生物学的深远影响已日渐显露。最近有人提议:内啡素的发现者应获诺贝尔奖。一、内啡素的发现六十年代初,我国学者邹冈等发现,给免第三脑室周围灰质注射微量吗啡可产生明显的镇痛作用,从而首次明确提出吗啡的中枢作用部位,但由于十年内乱中止了这项极有前途的研究。约十年后,西德学
Since the discovery of the endogenous opioid (morphine) -like substance (abbreviated as endorphin) in 1975, the research in this field has been very active. Until 1982, there were over 10,000 articles on the subject. Melzack and Wall, the world-renowned authoritative authority on pain research and the founder of allodynia control theory, claim that the results of this period were a major breakthrough in the field of pain and pain relief research. However, the significance of endorphins is much more than that, and its profound influence on the entire medical and biological sciences has become increasingly apparent. It has recently been proposed that the discoverer of endorphins should receive the Nobel Prize. First, the discovery of endorphin The early sixties, our country scholar Zou Gang found that the injection of trace morphine in the periventricular gray matter produced significant analgesic effect, which for the first time made it clear that the central role of morphine site, but as ten This year’s chaos stopped this promising study. About ten years later, West Germany