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目的探讨超促排卵过程中小卵泡穿刺术对治疗顽固性多囊卵巢综合征(PCOS)患者的临床应用。方法选取对克罗米芬(CC)及尿促性腺激素促排卵抵抗的顽固性PCOS不育患者共42例44周期,采用体外受精-胚胎移植(IVF-ET)技术助孕,随机分为2组,超促排卵过程中,因卵泡发育慢卵泡多,雌二醇(E2)增高,采用小卵泡穿刺术并继续治疗周期,与未穿刺周期比较在平均促性腺激素(Gn)使用天数、Gn用量、OHSS发生率、周期取消率、受精率及妊娠率等方面进行比较。结果穿刺组OHSS发生率、周期取消率、受精率及妊娠率等均较未穿刺组明显改善(P<0.05)但平均Gn天数及Gn量增加(P<0.05)。结论对顽固性PCOS患者采用IVF助孕,促排卵过程中采用小卵泡穿刺治疗是一种安全的、成功率比较可靠的治疗方法,但可能使患者治疗费用增加。
Objective To investigate the clinical application of small follicle aspiration in the treatment of patients with refractory polycystic ovary syndrome (PCOS). Methods Forty-two 44 cycles of refractory PCOS infertility with clomiphene citrate (CC) and urinary gonadotrophin (OVX) -resistant ovulation induction were enrolled in this study. Pregnancy was assisted by in vitro fertilization-embryo transfer (IVF-ET) In the course of superovulation, follicles developed more follicles, increased estradiol (E2), follicular puncture, and continued treatment cycles. Compared with the non-punctured cycles, the average number of gonadotrophin (Gn) days, Gn dosage, OHSS incidence, cycle cancellation rate, fertilization rate and pregnancy rate were compared. Results The incidence of OHSS, cycle cancellation rate, fertilization rate and pregnancy rate in puncture group were significantly improved (P <0.05), but the average number of Gn days and Gn increased (P <0.05). Conclusion The treatment of refractory PCOS patients with IVF-assisted pregnancy, ovulation induction by follicular puncture is a safe, more reliable success rate of treatment, but may increase the cost of treatment of patients.