机体的生理功能及生物化学方面的变化，具有呈一定周期性的机体节律，其中尤其是以24h为周期的昼夜节律，与药物疗效、毒性和体内过程有关。有些药物根据同机体节律相协调用药，可更有效地进行合理的药物疗法。对于抗肿痛药物，最近从研究正常细胞和肿瘤细胞的细胞周期，也开始 The body’s physiological functions and biochemical changes, with a certain period of the body’s rhythm, especially in the cycle of 24h circadian rhythm, and drug efficacy, toxicity and in vivo processes. Some drugs based on coordination with the body’s rhythm medication, more effective drug therapy can be reasonable. For anti-tumoral drugs, the recent study from the normal cell and tumor cell cycle, also started