论文部分内容阅读
目的探讨老年支气管哮喘患者呼出气一氧化氮与肺功能的相关性。方法选择2012年4月至2015年10月符合诊断标准的62例老年支气管哮喘患者作为观察组,选择同期体检结果肺功能正常者60例作为对照组。比较两组研究对象肺功能与呼出气一氧化氮(Fe NO)检测值,跟踪随访半年,比较观察组患者不同时期Fe NO与肺功能各项指标。结果观察组Fe NO[(16.82±2.73)μg/L]低于对照组[(27.34±3.81)μg/L],差异有统计学意义(P<0.05)。观察组最大呼气流量(PEF)、第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占预计值百分比(FEV1%pred)水平低于对照组,差异有统计学意义(P<0.05)。观察组患者在病情完全控制期的Fe NO水平低于良好控制期与未控制期水平,差异有统计学意义(P<0.05)。患者病情在完全控制期时PEF、FEV1及FEV1%pred水平均高于未控制期,差异有统计学意义(P<0.05),也高于良好控制期,但差异未见统计学意义(P>0.05)。结论 Fe NO与肺功能检查对于临床诊断老年支气管哮喘具有重要意义,但Fe NO还可准确反映疾病进展情况,为指导临床治疗提供依据。
Objective To investigate the relationship between exhaled nitric oxide and pulmonary function in elderly patients with bronchial asthma. Methods Sixty-two elderly patients with bronchial asthma who met the diagnostic criteria from April 2012 to October 2015 were selected as the observation group and 60 patients with normal lung function during the same period were selected as the control group. The lung function and exhaled nitric oxide (NO) were compared between the two groups and followed up for six months. The indexes of Fe NO and pulmonary function in different periods were observed. Results The Fe NO [(16.82 ± 2.73) μg / L] in the observation group was significantly lower than that in the control group [(27.34 ± 3.81) μg / L], the difference was statistically significant (P <0.05). The maximum expiratory flow (PEF), forced expiratory volume in 1 second (FEV1) and FEV1% pred in 1 second were significantly lower in the observation group than those in the control group (P <0.05). The level of FeNO in observation group was lower than that in control period and uncontrolled period. The difference was statistically significant (P <0.05). The levels of PEF, FEV1 and FEV1% pred were significantly higher in patients with complete control than those in control (P <0.05), but also higher than those in control (P> 0.05). Conclusion Fe NO and pulmonary function tests are of great significance for clinical diagnosis of elderly bronchial asthma, but Fe NO can accurately reflect the progress of the disease and provide the basis for clinical treatment.