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1病例资料患者,女,48岁,因“心慌、乏力3个月”于2011年10月7日入院,既往体健。体检:中度贫血貌,浅表淋巴结未触及,心肺听诊无明显异常,腹软,肝脾肋下未及。血常规:WBC 35.4×109/L,Hb68g/L,PLT 144×109/L。骨髓涂片:有核细胞增生极度活跃,原幼细胞占0.875,细胞圆形,核质比例高,核圆形,染色质致密,可见核仁,胞质透明,多数细胞内可见较多的粗大紫红色颗粒,多数分布胞质中,且聚集胞质一侧,少数覆盖核上,细胞间未见散落的颗粒(图1)。外周血涂片:可见颗粒幼稚淋巴细胞(占0.12),胞质可见粗大的颗粒,主要分布在胞质中。细胞化学染色:过氧化物酶(POX)染色
1 Case data Patient, female, 48 years old, admitted to hospital on October 7, 2011 because of “painful, fatigued 3 months”. Physical examination: Moderate anaemia appearance, superficial lymph node untouched, no abnormal heart and lung auscultation, soft abdomen, no liver and spleen ribs. Blood routine: WBC 35.4×109/L, Hb68g/L, PLT 144×109/L. Bone Marrow Smear: extremely proliferating nucleated cells, 0.875 protoskeletal cells, round cells, high proportion of nucleoplasms, round nucleus, compact chromatin, visible nucleoli, transparent cytoplasm, most cells can be seen in more coarse Purple-red particles, mostly distributed in the cytoplasm, and on the side of the aggregated cytoplasm, a few covering the nucleus, no scattered particles between cells (Figure 1). Peripheral blood smears: young granular lymphocytes (0.12) were visible, and large particles were seen in the cytoplasm, mainly in the cytoplasm. Cytochemical staining: Peroxidase (POX) staining