为观察牛磺酸对氯化钙引起的大鼠心律失常的保护作用，采用经股静脉推注氯化钙生理盐水溶液，建立ＳＤ大鼠心律失常模型，以大鼠发生心率失常频率、强度为指标，比较腹腔预防注射牛磺酸对钙诱发心律失常的对抗作用。结果：剂量为１００ｍｇ／ｋｇ氯化钙生理盐水溶液使全部受试大鼠不同程度地出现心律失常，给牛磺酸２００ｍｇ／ｋｇ，腹腔注射、每ｄ２次、共２ｄ，能减轻模型组室颤发生率（Ｐ＜０．０２５）及死亡率（Ｐ＜０．０１）。提示牛磺酸对氯化钙引起的大鼠心律失常有预防作用。 In order to observe the protective effect of taurine on arrhythmia induced by calcium chloride in rats, the rat model of cardiac arrhythmia was established by injecting calcium chloride physiological saline solution through the femoral vein. The frequency of arrhythmia was Indicators, compared peritoneal injection of taurine on calcium-induced arrhythmia antagonism. Results: The normal saline solution (100mg / kg) caused some arrhythmias in all the rats. Taurine 200mg / kg, intraperitoneal injection, d2 times per day for 2 days reduced the arrhythmia Incidence (P <0.025) and mortality (P <0.01). Tip taurine on rat heart caused by calcium chloride arrhythmias have a preventive effect.