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目的 了解广州地区脑血管病病人感染产超广谱 β -内酰胺酶革兰阴性杆菌情况及对 18种抗生素耐药性进行调查分析。方法 对广州 12家医院分离的 3 499株革兰阴性杆菌 ,其中包括分离自神经内科、神经外科脑血管病病人 3 89株 ,检测其超广谱 β -内酰胺酶 ,并以K -B法检测所有菌对 18种抗生素的敏感性。结果 广州地区常见革兰阴性杆菌产超广谱 β -内酰胺酶总体检出率 3 8.4% (819/213 4) ;神经科脑血管病病人超广谱β -内酰胺酶检出率 5 5 .5 %(12 1/2 18) ;其中大肠埃希菌、肺炎克雷伯菌的检出率分别是 5 3 .1%、5 7.5 %。结论 广州地区脑血管病病人大肠埃希菌、肺炎克雷伯菌超广谱 β -内酰胺酶检出率与总体检出率比较有统计学意义 (P <0 .0 1) ,18种抗生素的耐药率所有产酶株与非产酶株比较有统计学意义。
Objective To understand the prevalence of extended - spectrum β - lactamase - producing gram - negative bacilli in patients with cerebrovascular disease in Guangzhou and to investigate the antibiotic resistance of 18 kinds of antibiotics. Methods A total of 3 499 Gram - negative bacilli isolated from 12 hospitals in Guangzhou, including 3 89 isolates from neurology and neurosurgery cerebrovascular disease patients, were tested for their extended - spectrum β - lactamases. The K - All bacteria were tested for their sensitivity to 18 antibiotics. Results The overall prevalence of extended - spectrum β - lactamases in Gram - negative bacilli in Guangzhou was 3 8.4% (819/213 4). The detection rate of extended - spectrum β - lactamases in patients with neurological cerebrovascular diseases was 5 5 .5% (12 1/2 18). The detection rates of Escherichia coli and Klebsiella pneumoniae were 53.1% and 7.57%, respectively. Conclusions The detection rate of ESBLs and Klebsiella pneumoniae in patients with cerebrovascular disease in Guangzhou is statistically significant (P <0. 01) and 18 kinds of antibiotics The resistance rate of all the enzyme producing strains and non-producing enzyme strains were statistically significant.