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目的探讨高强度聚焦超声(HIFU)对恶性肿瘤患者细胞免疫功能的影响。方法取52例恶性肿瘤患者HIFU治疗前和治疗后7d外周血2ml,用流式细胞仪检测NK、rdT、CD4+T、CD8+T细胞百分数和CD4+/CD8+。结果经HIFU治疗后患者的NK细胞、rdT细胞百分数显著升高(P<0.05),CD4+T细胞百分数和CD4+/CD8+比值明显升高(P<0.05),CD8+T细胞百分数则下降(P<0.05)。结论HIFU既能非侵入性、微创、准确、适形灭活肿瘤,又能提高恶性肿瘤患者机体内的细胞免疫功能。
Objective To investigate the effect of high intensity focused ultrasound (HIFU) on cellular immune function in patients with malignant tumor. Methods Peripheral blood samples were obtained from 52 patients with malignant tumor before treatment and 7 days after treatment. The percentage of NK, rdT, CD4 + T, CD8 + T cells and CD4 + / CD8 + were detected by flow cytometry. Results The percentages of NK cells and rdT cells were significantly increased (P <0.05), the percentage of CD4 + T cells and CD4 + / CD8 + were significantly increased (P <0.05) and the percentage of CD8 + T cells was decreased after HIFU treatment <0.05). Conclusions HIFU can not only invade the tumor by minimally invasive, accurate and conformal therapy, but also improve the cellular immune function in the malignant tumor patients.