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目的：探讨可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）在多发性硬化（ＭＳ）发病机理中的作用及其临床意义。方法：采用双抗体夹心ＥＬＩＳＡ法对４４例ＭＳ患者脑脊液ｓＩＬ－２Ｒ水平进行了检测。结果：ＭＳ组脑脊液ｓＩＬ－２Ｒ水平显著高于正常对照组，脑脊液ｓＩＬ－２Ｒ水平变化与ＭＳ患者疾病活动状态及病残程度密切相关。结论：ＭＳ患者体内Ｔ淋巴细胞处于活化状态，ｓＩＬ－２Ｒ在ＭＳ发病机理中发挥着重要作用，检测脑脊液ｓＩＬ－２Ｒ水平对判断ＭＳ病情及疾病状态、指导ＭＳ治疗有重要的临床意义。
Objective: To investigate the role of soluble interleukin 2 receptor (sIL-2R) in the pathogenesis of multiple sclerosis (MS) and its clinical significance. Methods: The levels of sIL-2R in cerebrospinal fluid of 44 MS patients were detected by double antibody sandwich ELISA. Results: The level of sIL-2R in cerebrospinal fluid of MS group was significantly higher than that of normal control group. The level of sIL-2R in cerebrospinal fluid was closely related to the disease activity status and degree of disability in MS patients. Conclusion: T lymphocytes in MS patients are activated, and sIL-2R plays an important role in the pathogenesis of MS. Detection of sIL-2R in cerebrospinal fluid is of great clinical significance in judging the disease status and disease status of MS and guiding the treatment of MS.