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目的:了解深圳市孕妇鼻腔定植的金黄色葡萄球菌(SA)和耐甲氧西林金黄色葡萄球菌(MRSA)的耐药谱情况。方法:收集深圳市龙华新区人民医院及中心医院入院待产孕妇鼻腔分离出的SA菌株,并采取纸片扩散法确定MRSA菌株和SA耐药情况。结果:共收集了SA 547株,其中MRSA 107株。MRSA对克林霉素、利福平、红霉素、青霉素及多重耐药的耐药情况与MSSA比较,差异均有统计学意义(P<0.001、P<0.001、P<0.001、P=0.012、P<0.001)。对孕妇的年龄进行分组后,可见不同年龄组对利福平、妥布霉素、红霉素、青霉素、替考拉宁、复方新诺明及多重耐药的耐药情况比较,差异均有统计学意义(P<0.001、P=0.012、P=0.034、P=0.009、P=0.008、P=0.004、P=0.003)。结论:本研究中孕妇鼻腔携带的SA和MRSA菌株的耐药率较高。另外,高龄孕妇和低龄孕妇的MRSA耐药性较严重应引起注意。
Objective: To investigate the drug resistance spectrum of nasal colonization of Staphylococcus aureus (SA) and methicillin-resistant Staphylococcus aureus (MRSA) in pregnant women in Shenzhen. Methods: SA strains isolated from nasal cavity of pregnant women were collected from Longhua New District People’s Hospital and Central Hospital of Shenzhen City, and the MRSA strains and SA drug resistance were determined by disk diffusion method. Results: A total of 547 strains of SA were collected, including 107 strains of MRSA. The differences of MRSA between clindamycin, rifampicin, erythromycin, penicillin and multi-drug resistance were statistically significant (P <0.001, P <0.001, P <0.001, P = 0.012 , P <0.001). After the grouping of pregnant women’s age, we can see the different age groups of rifampicin, tobramycin, erythromycin, penicillin, teicoplanin, cotrimoxazole and multi-drug resistance were compared, the difference was Statistical significance (P <0.001, P = 0.012, P = 0.034, P = 0.009, P = 0.008, P = 0.004, P = 0.003). Conclusion: The drug resistance rates of SA and MRSA strains carried by the nasal cavity of pregnant women are high in this study. In addition, older pregnant women and younger pregnant women should be more serious MRSA resistance should pay attention.