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目的:研究肾安康胶囊改善急性肾功能衰竭(ARF)模型大鼠的血生化指标和排尿作用。方法:灌胃给予血红蛋白尿模型大鼠不同剂量的肾安康胶囊后,取血观察其血尿素氮(BUN)和血清肌酐(Scr)水平,以及每天排尿量。结果:该药高、低剂量组对血红蛋白尿模型大鼠的BUN水平均无明显改变;而能不同程度的降低模型大鼠的Scr水平;其高、低剂量组均可改善模型大鼠的排尿量。结论:肾安康胶囊对急性肾功能衰竭模型大鼠有一定的保护作用。
Objective: To investigate the effect of Shenkang Capsule on blood biochemical parameters and urinary excretion in rats with acute renal failure (ARF). Methods: The rats were given different doses of Shenkang Capsule by intragastric administration of hemoglobinuria model rats. The levels of blood urea nitrogen (BUN) and serum creatinine (Scr) were measured by blood and the daily urine output was measured. Results: The BUN levels of hemoglobinuria model rats did not change significantly in the high and low dose groups, but Scr levels of the model rats were decreased to some extent. Both high and low dose groups could improve the urination of the model rats the amount. Conclusion: Shenkang Capsule can protect rats with acute renal failure.