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本文应用体内体外试验法观察吡喹酮对日本血吸虫卵的作用。 30只DDD株小鼠,每鼠经皮感染日本血吸虫尾蚴60条,于感染后7周进行试验。吡喹酮混悬液的剂量为100mg/kg,在1天内共灌服4次,并设不服药小鼠作对照。两组小鼠于服药后1天和1、2、4和8周,每组各解剖3鼠,观察肝移和门静脉内的虫数,以及每鼠肠壁内计数900个虫卵,观察卵谱变化。结果:感染小鼠灌服吡喹酮后虫体肝移率达100%,而对照组为0～15.4%。小鼠于服药后1天,成熟虫卵减少,新近排空的卵壳增加;1周后,成熟虫卵增加,以后减少;2周后,近期死卵比例最高,其后逐渐减少,而钙化虫卵则持续增多。对照鼠在相应时间内未
In this paper, in vitro and in vivo test of praziquantel observe the role of Schistosoma japonicum eggs. Thirty DDD mice were inoculated with 60 cercariae of Schistosoma japonicum transdermally in each mouse and tested 7 weeks after infection. Praziquantel suspension dose of 100mg / kg, a total of 4 times within 1 days, and set the control mice were not taken. Two groups of mice were dosed 1 day and 1, 2, 4 and 8 weeks after operation, 3 mice were dissected in each group. The number of worms in liver transplantation and portal vein were observed, and 900 eggs Spectrum changes. Results: In mice infected with praziquantel, the rate of liver metastasis was 100%, while the control group was 0-15.4%. One day after taking the medicine, the number of mature eggs decreased and the number of newly emptied egg shells increased. After 1 week, mature eggs increased and then decreased. After 2 weeks, the proportion of dead eggs was the highest in the recent period and then decreased gradually, Egg is continuously increased. Control mice in the corresponding time not