近30％的人类肿瘤中有突变而导致其活性升高的Ras,是酪氨酸激酶信号通路的重要调节分子,过度表达或活化可使信号通路活性增强,引起细胞无限增殖和癌变。以往人们总是通过使用抑制剂下调Ras信号通路的方法达到治疗肿瘤的目的。本研究发明呼肠弧病毒可通过活化的Ras信号通路消除肿瘤。 人成胶质细胞瘤U87细胞可过度表达血小板衍生的生长因子受体(PDGFR),且Ras高度活化。作者将对呼肠弧病毒易感的人成胶质细胞瘤U87 Ras, which is mutated in nearly 30% of human tumors and leads to increased activity, is an important regulator of the tyrosine kinase signaling pathway. Overexpression or activation can increase the activity of signaling pathways, causing cell proliferation and canceration. In the past, people always used the inhibitor to down-regulate the Ras signaling pathway to achieve the purpose of treating tumors. The present invention reoviruses can eliminate tumors through activated Ras signaling pathway. Human glioblastoma U87 cells overexpress platelet-derived growth factor receptor (PDGFR), and Ras is highly activated. The authors will be susceptible to reovirus-producing human glioblastoma U87