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目的 :探讨与糖尿病肾病 (DN)发病有关的危险因素。方法 :对 1997～ 1998年间山东沿海地区糖尿病血管并发症调查中的 40 8例 2型糖尿病患者 (其中有 DN者 171例 ,无 DN者 2 37例 )进行分析研究。结果 :DN组年龄、病程、血糖、血压、血脂、纤维蛋白原水平均高于无 DN组 ,视网膜病变发生率及冠心病发生率显著高于无 DN组(P均 <0 .0 0 1)。多元线性回归分析显示病程、纤维蛋白原、甘油三酯、收缩压升高与 DN发病显著正相关。结论 :积极控制血压、血糖、纠正血脂紊乱等是预防和延缓 DN发生和发展的重要措施。
Objective: To investigate the risk factors associated with the pathogenesis of diabetic nephropathy (DN). Methods: Forty-eight patients with type 2 diabetes mellitus (171 with DN, and 237 with DN) from the survey of vascular complications of diabetes in Shandong coastal area from 1997 to 1998 were analyzed. Results: The age, course of disease, blood glucose, blood pressure, blood lipid and fibrinogen in DN group were significantly higher than those without DN group. The incidence of retinopathy and the incidence of coronary heart disease in DN group were significantly higher than those without DN group (all P <0.01). Multivariate linear regression analysis showed that the course of disease, fibrinogen, triglycerides, elevated systolic blood pressure and DN were significantly positively correlated. Conclusion: Positive control of blood pressure, blood glucose, and correction of dyslipidemia are important measures to prevent and delay the occurrence and development of DN.