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目的:评估中药妊娠退黄汤、西药熊去氧胆酸(UDCA)治疗妊娠期肝内胆汁淤积症(ICP)的效果。方法:32例患者随机分成二组,A组 UDCA15mg/kg·d,10天为一个疗程;B组妊娠退黄汤,每日一剂,10 天为一疗程。结果:两组治疗后瘙痒、转氨酶、胆汁酸明显下降(p< 0．05),组间无差异(p>0．05)。停药后瘙痒、胆汁酸、肝酶出现反跳现象有明显差异(p<0．05)。结论:UDCA和妊娠退黄汤治疗ICP是安全有效的,但妊娠退黄汤治疗ICP后不易出现瘙痒及生化指标的反跳。
OBJECTIVE: To evaluate the effect of traditional Chinese medicine, “Pregnancy Decoction” and “UDCA” in treating intrahepatic cholestasis of pregnancy (ICP). Methods: 32 patients were randomly divided into two groups, A group UDCA15mg / kg · d, 10 days for a course of treatment; B group pregnant decoction, a day, 10 days for a course of treatment. Results: The pruritus, aminotransferase and bile acid were significantly decreased in both groups (p <0.05). There was no difference between the two groups (p> 0.05). After stopping the itching, bile acid, liver enzymes rebound phenomenon was significantly different (p <0.05). Conclusion: UDCA and Pregnancy Decoction for the treatment of ICP is safe and effective, but pregnancy Decoction treatment of ICP is not prone to pruritus and biochemical indicators of the rebound.