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目的：探讨胸腺肽肠溶片配合化疗对非小细胞肺癌患者的细胞免疫功能及细胞因子的影响。方法将86例非小细胞肺癌患者随机分为单纯接受化疗的对照组和接受口服胸腺肽肠溶片联合化疗的实验组，分别检测两组患者的外周血单核细胞（peripheral blood mononuclear cells, PBMC）中化疗前后CD4+T淋巴细胞、CD8+T淋巴细胞所占的比例，并同时检测外周血中Th1、Th2细胞所分泌的细胞因子水平。结果治疗后，实验组的PBMC中CD4+T细胞所占比例以及CD4+T与CD8+T的比值均高于对照组，而CD8+T细胞则明显低于对照组，差异均有统计学意义（P＜0.05）。并且实验组患者的PBMC中IFN-γ、TNF-α、IL-2水平均高于对照组，差异有统计学意义（P＜0.05）；而IL-4、IL-6、IL-10水平则低于对照组，两者差异有统计学意义（P＜0.05）。结论化疗同时配合口服胸腺肽肠溶片可以较好改善非小细胞肺癌患者的细胞免疫功能，有助于临床肿瘤治疗。“,”Objective To observe the effect of thymopeptides enteric-coated tablets combined chemotherapy on cellular immunologic function of non-small cell lung cancer patients.Methods 86 non-small cell lung cancer patients were divided into two groups, control group and observation group. Both groups accepted chemotherapy, and the observation group took thymopeptides enteric-coated tablets additionally. Then, we detected the proportion of CD4+T lymphocytes, CD8+T lymphocytes in PBMC (peripheral blood mononuclear cells) as well as the level of cytokines secreted by Th1 and Th2 cells.Results The proportion of CD4+T lymphocytes in PBMC and the ratio of CD4+T lymphocytes to CD8+T lymphocytes in observation group were higher than that in control group, as well as the levels of IFN-γ,TNF-α and IL-2. But the levels of IL-4, IL-6 and IL-10 in observation group were lower than that in control group.Conclusion Thymopeptides enteric-coated tablets improved immunologic function of non-small cell lung cancer patients who had accepted chemotherapy.