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近年来,对存在于血中的分子量在350～5000道尔顿之间的中分子量物质(下称中分子)已引起广泛重视,并进行了大量研究。70年代初期,有人提示中分子作为尿毒症中毒本源性物质的假说已得到证实。又有人证明,中分子除参与尿毒症发病外,还参与其它多种疾病的发病机制。关于糖尿病患者血中中分子含量及其临床意义的研究,国内外均未见报导。为此,本文的目的旨在观察不同重度糖尿病患者血中中分子含量的改变及其临床意义。一、观察对象和方法观察了45例住院及门诊糖尿病患者。其中男25例,女20例;年龄15～73岁。根据血糖浓度和临床表现,给予胰岛素或口服降血糖药物治疗,并进行饮食控制。按规定时间同步测定患者空腹静脉血中中分子、血糖、尿素氮、肌酐含量等生化指标以及尿常规检查。除一般表现外,临床主要观察慢性并发症:白内障、眼
In recent years, there has been extensive attention paid to middle molecular weight substances (hereinafter referred to as middle molecules) having a molecular weight between 350 and 5000 daltons in the blood, and a large amount of research has been conducted. In the early 1970s, it was suggested that the hypothesis that the middle molecules act as the source substance of uremia poisoning has been confirmed. Others have shown that in addition to participating in the pathogenesis of uremia, but also involved in the pathogenesis of many other diseases. On the blood of diabetic patients in the molecular content and clinical significance of the study, both at home and abroad have not been reported. To this end, the purpose of this paper is to observe the changes in the blood of different patients with severe diabetes and its clinical significance. First, the observed objects and methods were observed in 45 cases of inpatients and outpatients with diabetes. Including 25 males and 20 females; aged 15 to 73 years. According to the blood glucose concentration and clinical manifestations, given insulin or oral hypoglycemic drugs, and diet control. Simultaneous determination of fasting venous blood in patients with blood glucose, blood urea nitrogen, creatinine and other biochemical indicators and urine routine examination. In addition to the general performance, the main clinical observation of chronic complications: cataracts, eyes