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目的:利用Meta分析法对米非司酮配伍米索前列醇与它们和其他药物联合应用于终止早期妊娠的临床试验进行分析,了解其在药物流产中作用的差异。方法:检索1995～2008年国内发表的米非司酮配伍米索前列醇,以及使用其他辅助药物联合该配伍应用于终止早期妊娠的临床试验的所有文献,分析对几项研究进行同质性检验和合并效应量的估计。结果:米非司酮配伍米索前列醇与它们和其他药物联合应用完全流产率的效应值(观察组和对照组疗效的比)OR=3.10,95%可信区间(2.28,4.23),并且不存在发表性偏倚。结论:米非司酮合并米索前列醇与其他药物合用终止早期妊娠的效果较单独使用有显著差异,其完全流产率明显优于不使用辅助药物。
OBJECTIVE: To analyze the clinical effects of mifepristone combined with misoprostol and their combination with other drugs in the termination of early pregnancy by Meta-analysis to understand the difference in the role of mifepristone in miscarriage. METHODS: We searched all articles published in China from 1995 to 2008, including mifepristone and misoprostol, and used other adjunctive drugs in combination with this drug in the clinical trial of termination of early pregnancy. We analyzed the homogeneity of several studies And the amount of combined effects estimates. RESULTS: The effect of mifepristone with misoprostol in combination with these and other medications on OR (OR = 3.10, 95% confidence interval (2.28, 4.23)) and There is no published bias. Conclusion: The combination of mifepristone and misoprostol combined with other drugs to terminate early pregnancy has significant difference compared with single use, and its complete abortion rate is obviously better than without auxiliary drug.