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甲氰咪胍(Cimetidine, Tagamet)是一种组织胺H_2受体拮抗剂,能有效地抑制胃酸分泌,缓解消化性溃疡的症状和促进溃疡愈合。1975年以来,用以治疗消化性溃疡取得满意的近期效果,普遍认为甲氰咪胍是治疗十二指肠球部溃疡的有效药物,优于其他制酸剂与抗胆碱药物。我院自1979年7月至1980年5月应用国产甲氰咪胍(上海医药工业研究院和上海第六制药厂试制)和国外同类产品Tagamet,对65例十二指肠球部溃疡患者采用双盲法进行治疗,观察与对比其疗效,现将结果报道如下。
Cimetidine (Tagamet) is a histamine H 2 receptor antagonist, which can effectively inhibit gastric acid secretion, relieve peptic ulcer symptoms and promote ulcer healing. Since 1975, satisfactory short-term results have been achieved for the treatment of peptic ulcer. Cimetidine is generally considered to be an effective drug for the treatment of duodenal ulcer. It is superior to other antacid and anticholinergic drugs. Our hospital from July 1979 to May 1980 application of domestic cimetidine (Shanghai Institute of Pharmaceutical Industry and Shanghai No. 6 Pharmaceutical Factory trial) and similar foreign products Tagamet, 65 cases of duodenal ulcer patients Double-blind treatment, observation and comparison of its efficacy, the results reported below.